GLP-1 receptor agonists like Ozempic, Wegovy, and Mounjaro have redefined weight loss. But relying solely on medication can backfire. Without the right fitness strategy, including strength training, users risk losing valuable muscle mass—impacting long-term metabolism and results.
At Prescription Fitness and Butler Fitness, we’ve seen firsthand how combining personalized training with GLP-1 support leads to exceptional, sustainable success.
Why Muscle Matters More Than Ever on GLP-1
GLP-1 medications reduce hunger and blood sugar levels, making weight loss easier. However, studies show that up to 30% of weight lost through these medications can come from lean muscle, not just fat. This matters because muscle is metabolically active—it helps you burn more calories at rest and sustain healthy weight management.
When muscle mass declines:
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Metabolism slows down
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Energy levels drop
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Body strength and function suffer
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Long-term fat loss becomes harder
Strength training combats all of this. It not only preserves muscle but can rebuild and increase it—even as you lose fat.
Supporting Stats: Why Strength Training Works
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The National Institutes of Health reports that resistance training improves insulin sensitivity and reduces fat mass, especially visceral fat.
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A 2022 study in Obesity Reviews found that participants combining GLP-1 medications with strength training lost significantly more fat mass and preserved muscle compared to medication-only groups.
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According to the American College of Sports Medicine, two to three resistance sessions per week is enough to maintain and grow muscle during weight loss.
Real Results: Mike Black’s Personalized Fitness Journey
Mike Black’s story is proof of what’s possible. Nearing 50 years old, Mike started with back pain, weight concerns, and a history of failed fitness attempts. Working with Prescription Fitness, Mike was guided through a tailored strength training program that respected his limits while delivering measurable progress.
Within weeks:
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His pain decreased
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His energy increased
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He started losing weight the right way—without sacrificing strength
“Prescription Fitness helped me regain my mobility, and now I’m stronger than I’ve been in decades,” Mike shares in his story. “This isn’t just weight loss—this is a complete transformation in how I live.”
Read Mike’s full story here.
The Role of Personal Trainers in GLP-1 Success
Starting GLP-1 medications can come with side effects like fatigue or nausea, which can disrupt workout routines. That’s why a certified personal trainer is critical. Our team:
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Adapts workouts to match your energy and goals
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Ensures proper technique to prevent injury
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Provides motivation and accountability during challenging weeks
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Coordinates fitness plans with your medication timeline
With us, you’re never on this journey alone.
Think Beyond the Prescription
Medications are a powerful tool—but they’re only part of the solution. Strength training fills in the gaps. At Prescription Fitness and Butler Fitness, we focus on your full transformation, combining expert guidance, science-based training, and compassionate support.
Don’t let muscle loss steal your momentum. Pair your prescription with a personalized fitness plan today.
Contact us for a free consultation and take the next step toward lasting success.

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